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Smallpox vaccine scars: What they look like and why

Posted on December 29, 2025 By admin

As a child, I noticed a strange scar high on my mother’s arm but forgot about it over the years. That curiosity returned when I saw the exact same scar on an elderly woman’s arm. When I asked my mother, she explained it came from the smallpox vaccine.

Before the 1970s, all children were vaccinated against smallpox, and the vaccine left a distinctive scar. Smallpox was a deadly disease, killing about 3 in 10 infected people, but widespread vaccination led to its eradication in the U.S. by 1952.

The scar formed because the vaccine was given using a two-pronged needle that punctured the skin multiple times, creating blisters that healed into a permanent mark.

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